NUTRISSOME® SP, a unique formula
Bioactive peptides, Gabolysat® Stress
These bioactive peptides of marine origin are the result of Laboratoire Dielen research. They are exclusive to the Dielen range. They are small proteins characterized by their small size. Their molecular weight of less than 1500 Daltons is at the origin of their bioavailability, i.e. their digestive absorption.
Their properties have been demonstrated in several studies published in scientific journals.
Gabolysat® Stress marine peptides are produced in Brittany using a patented process, from wild fish caught in the North Atlantic. Laboratoire Dielen has selected a number of everyday fish species whose resources are not threatened. Their sustainable fishing in France is controlled by European regulations. These fish are not fished specifically for this production, but rather Laboratoire Dielen valorizes certain by-products to extract bioactive marine peptides.
The double release of melatonin
The Nutrissome® SP tablet is an innovation patented by Laboratoire Dielen.
This film-coated tablet is the first dual-release melatonin device:
- Sublingual release: rapid release under the tongue. The sublingual route avoids degradation by the liver. It promotes rapid melatonin action.
- Sustained release: delayed, continuous release throughout the night. After swallowing, the tablet core slowly dissolves during the first hours of the night, gradually releasing the melatonin and nutritional complex.
The nutritional complex
As we age, the brain produces less melatonin. This drop in production can be the cause of difficulty falling asleep.
Melatonin is produced by the brain from a precursor: tryptophan. It also requires specific trace elements and vitamins that act as enzymatic cofactors.
That's why Nutrissome® SP combines bioactive marine peptides with tryptophan, melatonin, vitamins D3, B1, B2, B3, B5, B6, B9, B12, magnesium and zinc.
Dielen gastro-protective film coating
Nutrissome® SP tablets benefit from the Dielen film coating, which protects nutrients from gastric acidity by delaying their release into the intestine. The film coating uses no chemical additives, only gums of natural origin.
Health benefits :
The sleep-inducing benefits of melatonin
Melatonin is a hormone produced in our brain by the epiphysis gland. Its main function is to provide our body with temporary cues, which is why it is essential to the circadian regulation of our sleep.
Melatonin has two main benefits for sleep:
- It helps you fall asleep quickly.
- It helps reduce the effects of jet lag.
A lack of melatonin production by the body can lead to sleep disturbances.
As melatonin is not considered an essential nutrient, no recommended daily intake has been established. On the other hand, scientific studies have shown that melatonin supplementation helps people to fall asleep.
Nutrissome® SP tablets provide 0.7 mg sublingual melatonin for rapid sleep on set and 1 mg sustained-release melatonin.
Diagram of Nutrissome film-coated tablet® SP double-release film-coated tablet.
A natural solution for jet lag
With jet lag, the sleep-wake cycle is disrupted, which also has repercussions on melatonin production and sleep.
For optimum effect on jet lag, Nutrissome® SP should be taken just before bedtime on the first day of travel, and for a few days after arrival at your destination.
Health claims
Melatonin helps you fall asleep quickly.
Melatonin helps reduce the effects of jet lag.
Directions for use
For whom, for what?
- Rapid sleep induction
- Long-lasting sleep
- Time difference
How many tablets?
We recommend taking 1 tablet a day, with a glass of water.
When should you take it?
Nutrissome® SP should be taken in the evening at bedtime.
The tablet is placed under the tongue for at least 30 seconds to release the sublingual melatonin. The tablet can then be swallowed with a little water.
For how long?
Supplementation is provided for 1 month, or as needed.
Sleep hygiene recommendations
Here are the recommendations recommended by the Sleep Centers in France. They are simple to implement, and form the basis for the management of sleep disorders.
- Respect the rhythm and duration of your sleep
- Don't put off falling asleep: biological clock
- Respect a bedtime ritual: reading, herbal tea, schedule...
- Avoid psychotonics in the evening: tea, coffee, energy drinks, alcohol...
- Avoid all screens at bedtime (blue light)
- Ensure total darkness of the room
- Maintain a moderate room temperature of 18°C
- Avoid visual, acoustic and intellectual stress before bedtime
- Avoid physical activity at least 3 hours before bedtime
- Eat lightly in the evening to aid digestion
- Get up at a fixed time every morning, including weekends
- Get moving during the day with outdoor activities in sunlight
- Consult your GP or a regional sleep center
How long does a box last?
At 1 tablet per day, each box contains 1 month of supplementation.
Precautions for use
- Not recommended for those allergic to fish.
- Not suitable for children under 18.
- Seek the advice of a healthcare professional if you are taking any other medication at the same time (particularly antidepressants, hypnotics or St. John's Wort), or if you have epilepsy, asthma or mood, behavior or personality disorders.
- Not recommended for people suffering from inflammatory or auto-immune diseases, pregnant or breast-feeding women, or for people who have to carry out activities requiring sustained vigilance and who may be at risk of drowsiness.
- Do not exceed the recommended daily dose.
- Keep out of reach of children.
- Not a substitute for a varied, balanced diet and a healthy lifestyle.
Composition
| For 1 tablet | % NRV | |
|---|---|---|
| Marine peptides Gabolysat® Stress | 225 mg | - - |
| L-Tryptophan | 200 mg | - |
| Melatonin | 1,7 mg | - |
| Proteochelated magnesium | 56 mg | 15% |
| Zinc bisglycinate | 1,5 mg | 15% |
| Vitamin D3 | 5 µg | 100% |
| Vitamin B1 | 0,55 mg | 50% |
| Vitamin B2 | 0,7 mg | 50% |
| Vitamin B3 | 8 mg | 50% |
| Vitamin B5 | 6 mg | 100% |
| Vitamin B6 | 1,4 mg | 100% |
| Vitamin B9 | 0,2 mg | 100% |
| Vitamin B12 | 2.4 µg | 100% |
- Fish protein hydrolysate (Gabolysat® peptides)
- L-tryptophan of plant origin
- Bulking agent: tricalcium phosphate
- Magnesium oxide and enzymatic rice protein hydrolysate (proteochelated marine magnesium)
- Carriers: xanthan gum, acacia gum
- Glazing agents: shellac, gum arabic
- Vitamin B3 (nicotinamide)
- Anticaking agent: magnesium stearate
- Zinc bisglycinate
- Vitamin B5 (calcium pantothenate)
- Vitamin B12 (cyanocobalamin)
- Vitamin D3 (cholecalciferol)
- Vitamin B6 (pyridoxine hydrochloride)
- Melatonin
- Vitamin B1 (thiamine hydrochloride)
- Vitamin B2 (riboflavin)
- Vegetable glycerin
- Vitamin B9 (folic acid)
- Sweetener of plant origin (stevia): steviol glycosides
Science:
- Average sleep time: 6h42 on weekdays and 7h26 on days off
- 73% of French people say they wake up at least once a night
- 25% admit to dozing during the day
- 40% say they suffer from sleep disorders [1].
- 23% are well taken care of [1].
The many biological functions of the human body are regulated by circadian rhythms. The main circadian clock is managed in the brain by the hypothalamus. It regulates the alternation of sleep-wake rhythms, internal body temperature and the secretion of certain hormones, as well as metabolic and dietary rhythms.
This biological clock "gives time to our body", yet it doesn't work in isolation, and many factors, known as "external synchronizers", influence its cycle. The most powerful synchronizer of the circadian rhythm is alternating light and darkness, but physical and social activity, as well as diet, also play an important role.
Melatonin is one of the essential "messengers" for our circadian clock. The secretion of this hormone prepares the body for rest and sleep. As soon as light levels fall, melatonin secretion increases. The body goes into "sleep mode". For a person with "normal" circadian regulation, melatonin levels will rise considerably around 9:00 p.m. (i.e. about 1 to 2 hours before the usual time for falling asleep) and peak melatonin release will be reached between 2:00 and 4:00 a.m.. Secretion then declines, and melatonin is no longer present during the day.
Melatonin is largely produced by the epiphysis. It is synthesized by the body in two stages from serotonin, which is derived from the transformation of tryptophan.
Melatonin biosynthesis includes several cofactors shown in the diagram below.
Melatonin acts on :
- Falling asleep: published data indicate that melatonin supplementation reduces the time taken to fall asleep (latency time) in people suffering from insomnia [2] [3]. The beneficial effect is obtained by consuming 1 mg of melatonin before bedtime.
- Jet lag: the authors of two reviews published in 2002 and 2009 respectively analyzed the results of 9 and 14 clinical trials: they concluded that melatonin was effective and safe in preventing or reducing the effects of jet lag. [4]. Its beneficial effect is obtained by consuming at least 0.5 mg of melatonin just before bedtime on the first day of travel and for a few days after arrival at the destination.
Although melatonin is produced naturally by the brain, it can be disrupted by certain behavioral or environmental factors.
Melatonin secretion is disrupted by inappropriate exposure to light. For example, exposure to blue light from screens (TV, computer, smartphone) can delay melatonin secretion, making it difficult to fall asleep. :
- Difficulty in falling asleep
- Multiple nocturnal awakenings,
- Delayed sleep phases,
- Complicated morning wake-up call,
These symptoms are usually accompanied by other signs of sleep deprivation:
- Fatigue during the day,
- Daytime sleepiness,
- Irritability,
- Loss of alertness,
- Difficulty concentrating,
- Mood disorders,
Melatonin absorption by the oral route is only 15%, due to degradation by the liver (hepatic first pass). Maximum blood concentration is reached in 15 and 90 minutes, depending on the dose [5] [6].
By avoiding the first hepatic passage, the sublingual form (under the tongue) facilitates melatonin assimilation [7].
The properties of Gabolysat® Stress peptides, developed and patented by Laboratoire Dielen, have been published in scientific journals. These studies have highlighted the beneficial effects of the peptides [8][9].
*Melatonin helps reduce the time to fall asleep.
**Melatonin helps reduce the effects of jet lag.
[1] OpinionWay poll for the Ramsay Foundation - 2017
[2] Brzezinski A, Vangel MG, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005 Feb;9(1):41-50.
[3] Buscemi N, Vandermeer B, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005 Dec;20(12):1151-8.
[4] Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag.Cochrane Database Syst Rev 2002;(2):CD001520.
[5] Vidal 2017
[6] Harpsøe et al. 2015
[7] Sublingual Bartoli et al. 2012
[8] Diazepam-like effects of a fish protein hydrolysate (Gabolysat PC60) on stress responsiveness of the rat pituitary-adrenal system and sympathoadrenal activity - F.BERNET, V.MONTEL, B.NOEL, JP.DUPOUY
[9] P.BUGARD, Étude clinique de la supplémentation de Gabolysat Stress chez les patients asthéno-dépressifs, Service de psychatrie de l'hôpital Henry Roussel, Paris, France: 1985
Frequently asked questions
Nutrissome ® SP tablet is placed under the tongue for 30 seconds, then swallowed. It should be taken 30 minutes before bedtime.
Melatonin is the body's natural hormone. Waking up can be done naturally. If you experience any side effects, please consult your pharmacist or contact the Dielen consultant pharmacist.
Nutrissome® SP provides a selection of nutritional vitamin and mineral cofactors. Tryptophan is an amino acid which is the metabolic precursor of serotonin and melatonin.
Nutrissome® SP is not recommended for pregnant and breastfeeding women, or for adolescents and children under 18.
Due to possible interactions between melatonin and certain medications, dietary supplements containing melatonin are not recommended for use with certain psychotropic drugs.
It is recommended to seek the advice of your doctor or pharmacist if you are taking any medication at the same time.
There are simple steps you can take to promote regular, quality sleep. Applying them is the basis of management, and if possible without resorting to medication.
- Respect the rhythm and duration of your sleep
- Don't put off falling asleep: biological clock
- Respect a bedtime ritual: reading, herbal tea, schedule...
- Avoid psychotonics in the evening: tea, coffee, energy drinks, alcohol...
- Avoid all screens at bedtime (blue light)
- Ensure total darkness of the room
- Maintain a moderate room temperature of 18°C
- Avoid visual, acoustic and intellectual stress before bedtime
- Avoid physical activity at least 3 hours before bedtime
- Eat lightly in the evening to aid digestion
- Get up at a fixed time every morning, including weekends
- Get moving during the day with outdoor activities in sunlight
- Consult your GP or a regional sleep center
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