MAGZEN®, a unique formula
Bioactive peptides, Gabolysat® Stress
These bioactive peptides of marine origin are the result of Laboratoire Dielen research. They are exclusive to the Dielen range.
Gabolysat peptides® Stress peptides are small proteins characterized by their low molecular weight. Their molecular weights of less than 1500 Daltons are the source of their properties.
Their properties have been demonstrated in several studies published in scientific journals.
Gabolysat® Stress marine peptides are produced in Brittany using a patented process and wild fish caught in the North Atlantic. At Laboratoire Dielen , we have selected everyday fish species whose resources are not threatened. Their sustainable fishing in France is controlled by European regulations. These fish are not caught specifically for Laboratoire Dielen, but rather the laboratory uses certain by-products to extract bioactive marine peptides.
Effect on stress and fatigue
The original Magzen® formula combines marine peptides with two amino and proteo-chelated magnesium salts. These salts are chosen for their good tolerability and bioavailability.
Laboratoire Dielen is based on bioavailability studies which highlight the assimilative qualities of magnesium bisglycinate and chelated marine magnesium.
Magzen* also contains vitamin B6, which helps reduce fatigue.
Dielen gastro-protective film coating
Magzen® tablets benefit from Dielen film coating, which protects nutrients from gastric acidity by delaying their release into the intestine. This coating uses no chemical additives, only gums of natural origin.
Health benefits :
Magnesium, an anti-stress ally
In stressful situations, the body uses more energy as a result of stimulation by stress hormones, notably adrenaline and cortisol*.
If stress lasts for a long time, it leads to a significant loss of magnesium. The result is a vicious circle. That's why we need to ensure an adequate intake of magnesium and vitamin B6**.
The virtues of magnesium
Magnesium also has the following benefits* :
- On bone health: magnesium helps maintain normal bone structure.
- Normal functioning of the nervous system: magnesium helps stabilize nerve membranes.
- On fatigue : magnesium plays a role in energy production. It thus contributes to normal brain function.
- Onmood balance: Magnesium contributes to normal psychological functions
Magnesium and athletes
Magnesium is important for muscle contraction and relaxation. It is also involved in the production of energy useful to muscles*.
The sweating that accompanies physical effort increases magnesium losses. A lack of magnesium can impair exercise capacity, as it affects energy production and muscular activity*.
This is why magnesium is particularly useful for the increased needs of athletes.
Vitamin B6 and magnesium
Vitamin B6 and magnesium are complementary in their mechanisms of action and nutritional properties.
Health claims
*Magnesium contributes to :
- reduce fatigue
- normal energy metabolism
- normal function of the nervous system
- normal muscle function
- normal protein synthesis
- normal psychological functions
- maintain normal bone structure
- maintain normal teeth
**Vitamin B6 contributes to :
- normal functioning of the nervous system
- normal psychological functions
- reduced fatigue
- regulation of hormonal activity
Directions for use
For whom?
- Stressed and tired people
- Overworked people
- Sportsmen
- Seniors
- Pregnant and nursing women
When should you take it?
It is advisable to stagger doses: 1 tablet in the morning and 1 in the evening.
How many tablets?
Take 1 to 2 tablets a day with a glass of water.
For how long?
A 3-month supplement, 1 to 3 times a year.
How long does a box last?
At 2 tablets a day, each box contains 30 days of supplementation.
Precautions for use
- Not recommended for those allergic to fish.
- Not suitable for children under 8.
- Keep out of reach of children.
- Store away from heat and moisture.
- Do not exceed the recommended daily dose.
- In cases of moderate renal impairment, monitoring may be required.
- Not a substitute for a varied, balanced diet or a healthy lifestyle.
Composition
| For 2 tablets | Daily intake for 2 tablets in NRVs*. | |
|---|---|---|
| TOTAL MAGNESIUM of which : | 300 mg | 80% |
| - Proteo-chelated magnesium | 270 mg | - |
| - Magnesium - Bisglycinate | 30 mg | - |
| Marine peptides Gabolysat Stress | 200 mg | - |
| Vitamin B6 | 1,4 mg | 100% |
- Proteo-chelated marine magnesium: magnesium oxide and rice proteins
- Bulking agent: microcrystalline cellulose
- Magnesium bisglycinate (10%)
- Fish protein hydrolysate (Peptides Gabolysat®)
- Bulking agent: croscarmellose sodium
- Anti-caking agents: mono and diglycerides of fatty acids, magnesium salts of fatty acids
- Glazing agent: shellac
- Pyridoxine hydrochloride (vitamin B6)
- Glazing agents: gum arabic, vegetable glycerin
- Natural aroma
Science: Magzen® - The scientific evidence for Laboratoire Dielen
The stress-reducing effect of supplementation was demonstrated by a multicenter clinical study on a population of 93 healthy but anxious subjects (Hamilton test above 20).
After 28 days of supplementation with 2 MAGZEN® tablets a day, 42% of subjects reduced their stress levels by more than half.
According to the doctors, 75% of subjects had a good to very good improvement in stress levels.
67% of subjects reported a good or very good improvement in their stress levels. Only 6% of patients experienced a rebound effect.
Reference: Oddoux, S.; Violette, P.; Cornet, J.; Akkoyun-Farinez, J.; Besnier, M.; Noël, A;. Rouillon, F. Effect of a Dietary Supplement Combining Bioactive Peptides and Magnesium on Adjustment Disorder with Anxiety: A Clinical Trial in General Practice. Nutrients 2022, 14, 2425. https://doi.org/10.3390/nu14122425
Stress is the body's reaction to a stressor, i.e. to a situation, whether aggressive or not.
9 out of 10 French people[1] experience stress. 50%.[1] consider themselves to be very or fairly stressed, and 24% [1[1] are in a state of hyper-stress.
The causes of stress are mainly due to professional life (36%).[1]), financial problems (35%[1]) and personal life (33%[1]), resulting in sleep problems (54%[1]), behavioral problems (35%[1]) and problems with family life (33%[1]).
79%[2] believe there are solutions to stress, and 29%[2] use complementary medicine.
Simple lifestyle recommendations can help you cope better with stress and avoid the risk of burnout:
- Eviction of the stressor
- Talk to someone close to you about your state of stress
- Consult the attending physician if necessary
- Regular, appropriate physical activity
- Relaxation or meditation exercises.
- A varied, Mediterranean-style diet
This advice can be complemented by magnesium supplementation. Magnesium deficiency is not always the cause of stress, but one of its consequences. Magnesium consumption alone cannot solve stress problems.
Magnesium is an essential trace element for our body. It is present in muscles, bones and liver,
Magnesium mediates numerous biochemical reactions, such as energy production, protein synthesis, muscle function and nerve impulse transmission.
According to data from the 2007 INCA 2 study by the French health safety agency ANSES[3], nutritional magnesium intake is inadequate for 89% of adolescents, 67% of adults and 77% of seniors.
In addition to age, gender and diet, a number of other factors can influence magnesium levels in the body. Prolonged stress, pregnancy, adolescence, intense physical activity, alcoholism, certain intestinal pathologies, certain medications and coffee consumption can all increase magnesium requirements.
Nutritional magnesium deficiency is characterized by nervous and physical fatigue, hyperemotionality, irritability, tingling, tremors, cramps, contractures, eyelid twitching and constipation.
Magnesium is not synthesized by the human body, so it must be supplied by our diet. It is present in many foods, such as cocoa powder, dark chocolate, almonds and hazelnuts. However, given the level of nutritional deficiency in part of the French population, supplementation for 3 months, 2 or 3 times, may be useful.
Vitamin B6 is an "essential" water-soluble vitamin, as the body can neither manufacture nor store it. It must be taken daily.
Vitamin B6 plays a cofactor role in a large number of protein metabolism processes. It plays a role in maintaining mental equilibrium.
Like most B vitamins, vitamin B6 is essential for the production of energy from muscle glycogen, which is the muscle's form of sugar storage.
They have been developed and patented by Laboratoire Dielen. Their properties have been demonstrated by several scientific studies, 4 of which have been published in international scientific journals. [ 7][8].
*Magnesium contributes to:
- reduce fatigue.
- normal energy metabolism.
- normal function of the nervous system.
- normal muscle function
- normal protein synthesis
- normal psychological functions
- maintain normal bone structure
- maintain normal teeth
**Vitamin B6 contributes to :
- Normal functioning of the nervous system
- Normal psychological functions
- reduce fatigue
- regulate hormonal activity
[1] Opinionway survey of 1017 people in October 2017
[2] Meteostress / IPSOS / Opinionway surveys (Oct 2017)
[3] Étude Individuelle Nationale des Consommations Alimentaires (INCA 2) 2006-2007. Agence Nationale de Sécurité Sanitaire de l'alimentation, de l'Environnement et du travail (ANSES), 2015 (Saisine n°2012-SA-0142).
[4] Abraham GE, Schwartz UD, Lubran MM. Effect of vitamin B-6 on plasma and red blood cell magnesium levels in premenopausal women. Ann Clin Lab Sci. 1981 Jul-Aug;11(4):333-6. PMID: 7271227
[5] Cowan JA. Structural and catalytic chemistry of magnesium dependent enzymes. BioMetals 2002; 15:225-235
[6] De Souza MC, Walker AF, Robinson PA, Bolland K. A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. J Womens Health Gend Based Med. 2000 Mar;9(2):131-9.
[7] Diazepam-like effects of a fish protein hydrolysate (Gabolysat PC60) on stress responsiveness of the rat pituitary-adrenal system and sympathoadrenal activity - F.BERNET, V.MONTEL, B.NOEL, JP.DUPOUY
[8] P.BUGARD, Étude clinique de la supplémentation de Gabolysat Stress chez les patients asthéno-dépressifs, Service de psychatrie de l'hôpital Henry Roussel, Paris, France: 1985
Frequently asked questions
There are different magnesium salts: oxide, citrate, malate, bisglycinate... Several factors distinguish them. In particular, their elemental magnesium content and bioavailability. In other words, their capacity for digestive absorption.
Laboratoire Dielen has chosen the 2 magnesium salts for which scientific studies show good bioavailability: bysglicinate and proteo-chelated marine.
One month's supplementation is recommended, but this depends on the individual's level of nutritional deficiency.
Magzen® was the subject of a clinical study published in 2021 in the international journal "Nutrients". The study was carried out by 17 doctors on 93 subjects in a recent state of stress. Significant results on stress were measured after 28 days' supplementation with 2 tablets a day.
Vitamin B6 helps regulate hormonal activity and reduce fatigue.
Proteo-chelated magnesium, also known as amino-complex, is a mixture of magnesium and peptides.
This blend of magnesium and peptides promotes magnesium bioavailability. Magnesium then uses the same absorption pathways as amino acids.
Magnesium overdosage is rare. Magzen® respects the Nutritional Reference Values (NRV), with a daily intake of 80% of the NRV for 2 tablets a day.
Magzen® is approved for pregnant and breastfeeding women
Magzen® is suitable for children aged 8 and over. The recommended minimum age is indicated on the box. It depends on the galenic form or the components of the formula.
This information is indicated on product pages and packaging.
Magzen® can be taken with certain families of medicines. However, it is preferable to seek the advice of a pharmacist who is familiar with drug interactions and precautions for use.
In addition, to avoid affecting the absorption of medication, it is important to stagger the intake of any dietary supplement by 2 hours.
A minimum of 3 months' supplementation is recommended.
Continuous supplementation is, however, useful for athletes and pregnant women due to their increased need for magnesium.
The 2 forms of amino and proteo-chelated magnesium are well tolerated by the digestive system, as they are well absorbed.
Laboratoire Dielen offers consumers an information service provided by a pharmacist advisor, available by e-mail and by telephone on 02 33 23 43 90.
