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DIELEN® D3+

Super vitamin D" for immune protection.

  • Combining vitamin D3 with its activating co-factor magnesium
  • Vitamin D & magnesium help maintain normal bone structure
  • Vitamin D & magnesium contribute to normal immune system function

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A unique formula
Health benefits
Directions for use
Composition
Science

DIELEN® D3+, a unique formula

Vitamin D3 combined with its co-factor, magnesium

The enzymes that convert vitamin D3 into active vitamin D work with magnesium, their enzyme cofactor.

That's why the Dielen® D3+ formula combines vitamin D3 with magnesium.

High-dose daily doses

70% of French people suffer from inadequate vitamin D intake. Dielen® D3+ provides a daily dose of 2,000 IU or 50 µg of vitamin D3 per capsule. It has been established that daily intake is better adapted to the body's daily needs.

Vitamin D3 solubilized in EPA/DHA omega-3s

Vitamin D3 is fat-soluble.  It must be accompanied by fats to promote its absorption. That's why Dielen® D3+' s formula solubilizes vitamin D3 into fish oil, which is rich in essential omega-3s.

Dielen gastro-protective film coating

Dielen® D3+ capsules benefit from the specific coating that protects the nutrients from gastric acidity by delaying their release into the intestine. Lamination does not use chemical additives , but only naturally occurring gums.

Health benefits :

The Benefits of Vitamin D

Vitamin D has multiple essential functions in the body:

Calcemia

Vitamin D contributes to normal blood calcium levels. It is involved in calcium absorption in the intestine and reabsorption in the kidneys.

It is important to respect the recommended doses to limit the risk of overdose and associated hypercalcemia.

On bones and skeleton

Bone structure owes its solidity to mineralization by calcium and phosphorus.

Vitamin D contributes to bone calcification.

On muscles, muscle function and the risk of falling

Vitamin D helps maintain muscle function. It is involved in muscle contraction and recovery***.

Vitamin D helps reduce the risk of falls in the elderly, associated with postural instability and muscular weakness, by around 30%. Falls in the elderly can lead to hospitalization or fractures with complications.

On the immune system

Immune system cells, or white blood cells, protect the body from pathogens. Vitamin D contributes to the normal functioning of the immune system, which ensures the body's natural defenses.

On the teeth

Teeth are protected by enamel. The hardness of enamel is linked to a process called remineralization. Through this process, minerals present in saliva help keep teeth strong. Vitamin D helps maintain normal dentition.

Beneath the enamel is dentin, which contains immune guard cells. Vitamin D also contributes to immune function.

Health claims

*Vitamin D contributes to the normal functioning of the immune system.

**Vitamin D and magnesium help maintain normal bone and muscle function.

***In adults aged 60 and over, vitamin D may help reduce the risk of falls. The beneficial effect is observed with a daily intake of 20 µg of vitamin D, from all sources.

Find out all about vitamin D, read our article on the subject.

Directions for use

For whom, for what?

  • Immunity and natural defenses
  • Maintaining the framework
  • Maintaining muscle function
  • Reducing the risk of falls

For how long?

Renewable supplementation for 3 months is recommended.

Dielen® D3+ can be taken over a long period of time.  Especially in winter as well as in people with a higher risk of nutritional deficiency:

  • The elderly,
  • Sportsmen and women,
  • People with pigmented skin,
  • People in institutions with little exposure to sunlight.

How long does a box last?

At a dose of 1 capsule per day, each pack contains 1 month of supplementation.

When should you take it?

At any time of day.

How many tablets?

We recommend taking 1 capsule a day, with a glass of water.

Precautions for use

  • For adults and adolescents over 12 years of age.
  • To be used in conjunction with a varied, balanced diet and a healthy lifestyle.
  • Not recommended for people allergic to fish.
  • Do not exceed the recommended dose.
  • Keep out of reach of children.
  • Pregnant and breast-feeding women should consult a health professional before taking any supplements.
  • Store in a cool, dry place, protected from light.

Composition

For 1 capsule% NRV
Vitamin D350µg - 2000UI1000%
Proteochelated marine magnesium56 mg15%
EPA Omega-3
Eicosapentaenoic acid		45 mg-
DHA Omega-3
Docosahexaenoic acid		27 mg-
*NRV: Reference Nutritional Value
Ingredients
  • Fish oils (antioxidants: tocopherols, rosemary extract)
  • Protein-coated marine magnesium: magnesium oxide and rice protein hydrolysate
  • Fish gelatin (shell)
  • Firming agent: plant-derived glycerin
  • Vitamin D3 (cholecalciferol)
  • Thickener: mono and diglycerides of fatty acids
  • Glazing agents: shellac, gum arabic
  • Emulsifier: rapeseed lecithin
  • Possible traces of shellfish.
Origin of components

Science: Dielen D3+ - The scientific evidence for Laboratoire Dielen

Vitamin D is a fat-soluble vitamin. It is soluble in fats.

It exists in the diet in 2 precursor forms:

  • vitamin D2, also known as ergocalciferol, which comes mainly from plant-based foods
  • vitamin D3, also known as cholecalciferol, which comes from foods of animal origin.

Vitamin D has 2 possible origins:

  • It comes from food.
  • It is synthesized in the skin, thanks to the action of the sun's rays (UVB) which transform cholesterol into vitamin D3.

Vitamin D3 is transported to the liver, where it is hydroxylated to calcidiol. This form is either stored in fat and liver or transformed in the kidneys into calcitriol, the active form of vitamin D. These reactions are made possible by enzymes in which magnesium is the enzymatic cofactor.

It's a good idea to expose your skin to the sun, but beware of overexposure, which can damage skin health. For this reason, it's best to prioritize outdoor activities, but protect yourself at midday.

Vitamin D reserves can be depleted in autumn and winter, as sunlight does not allow sufficient synthesis of vitamin D3. It is therefore necessary to obtain other sources of vitamin D through diet and supplementation.

Foods rich in vitamin D are often under-consumed. This partly explains the nutritional deficit in France.

Here is a non-exhaustive list of foods rich in vitamin D, in descending order, taken from the Ciqual table (reference database on the nutritional composition of foods in France):

  • Cod liver oil: 250 µg vitamin D per 100 g.
  • Herring: between 10 and 22 µg of vitamin D per 100 g
  • Rainbow trout: 15 µg vitamin D per 100 g.
  • Canned sardines: between 10 and 13 µg per 100 g
  • Salmon: between 8 and 13 µg of vitamin D per 100 g.
  • Eggs: the yolk contains 11 µg per 100 g.
  • Tuna: 7 µg vitamin D per 100 g.
  • Smoked salmon: 5 µg vitamin D per 100 g.
  • 70% cocoa dark chocolate: 2.16 µg vitamin D per 100 g.

Because dietary intake is often insufficient, it is useful to supplement regularly in the following cases:

 

  • Adults: in autumn, winter and spring if sun exposure is low.
  • Hospitalized or institutionalized patients
  • Sportsmen and women
  • The elderly.
  • People with little pigmentation

 

The minimum duration of supplementation is 3 consecutive months, renewable.

Supplements can be taken regularly, but in recommended doses.

  • Do not exceed a dose of 50 µg or 2000 IU per day. Regular daily intake is beneficial.
  • Prefer dietary supplements containing at least one source of fat. Vitamin D is fat-soluble, and is best absorbed when accompanied by a lipid.
  • Combine with magnesium for vitamin D3 conversion.

Several scientific studies show that daily vitamin D intake is nutritionally more interesting, as it is better adapted to the body's ongoing metabolic needs. [2] [3]

In the body, the enzymes that convert vitamin D3 into vitamin D work with magnesium, which acts as an enzyme cofactor.

These vitamin D biosynthesis reactions take place in the blood, liver and kidneys. The diagram below illustrates the biochemical reactions involved in converting the D3 form into vitamin D.

Health claims

*Vitamin D contributes to the normal functioning of the immune system.

*Vitamin D and magnesium help maintain normal bone and muscle function.

*Vitamin D reduces the risk of falls in the elderly associated with postural instability and muscular weakness.

Excess vitamin D should be avoided.

In fact, at high doses (> 250 µg/day), vitamin D can lead to excess calcium in the blood (hypercalcemia), or in the urine (hypercalciuria), facilitating the formation of kidney stones.

 

In healthy adults, the European health authorities (EFSA) recommend not exceeding a dose of 250 µg / day, i.e. 20,000 IU / day.

In France, the maximum dose permitted in food supplements is 50 µg or 2000 IU / day.

References

[1] OpinionWay poll for the Ramsay Foundation - 2017

[2] Brzezinski A, Vangel MG, et al. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005 Feb;9(1):41-50.
[3] Buscemi N, Vandermeer B, et al. The efficacy and safety of exogenous melatonin for primary sleep disorders. A meta-analysis. J Gen Intern Med. 2005 Dec;20(12):1151-8. [4] Herxheimer A, Petrie KJ. Melatonin for the prevention and treatment of jet lag.Cochrane Database Syst Rev 2002;(2):CD001520.

[5] Vidal 2017

[6] Harpsøe et al. 2015

[7] Sublingual Bartoli et al. 2012

[8] Diazepam-like effects of a fish protein hydrolysate (Gabolysat PC60) on stress responsiveness of the rat pituitary-adrenal system and sympathoadrenal activity - F.BERNET, V.MONTEL, B.NOEL, JP.DUPOUY

[9] P.BUGARD, Étude clinique de la supplémentation de Gabolysat Stress chez les patients asthéno-dépressifs, Service de psychatrie de l'hôpital Henry Roussel, Paris, France: 1985

Frequently asked questions

For healthy adults, the French health authorities recommend not exceeding 50 µg or 2,000 IU of vitamin D3 per day.

Dielen® D3+ provides the optimal daily dose with only 1 capsule per day.

They tell you about it

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