OSTÉOCALM® GEL, a unique formula
Marine collagen peptides, Promerim® Chondro
This marine active ingredient is the result of Laboratoire Dielen research. It is produced in Brittany from a selection of fish caught in the North Atlantic.
The process developed and patented by Laboratoire Dielen produces small collagen peptides known as Very Low Molecular Weight (VLMW ). Their weight is less than 1500 daltons. They are therefore composed of 2 to 15 amino acids.
These TBPM collagen peptides have special properties because they are bioavailable, i.e. assimilable by the body. Their properties have been studied historically in studies published in scientific journals.
Promerim® collagen peptides® Chondro collagen peptides differ from other collagens in their :
- geographical origin: French (Brittany)
- marine origin: selections of wild fish species
- structure: low molecular weight (LMW) collagen peptides
- production process: patented gentle hydrolysis
- bioactivity: joint studies
Laboratoire Dielen has selected everyday fish species whose resources are not threatened. Their sustainable fishing in France is controlled by European regulations. These fish are not caught specifically for this production. Instead, Laboratoire Dielen extracts bioactive collagen peptides fromcertain collagen-rich by-products.
The effectiveness of cryotherapy
Ostéocalm® Gel combines the effectiveness of collagen peptides with that of cryotherapy thanks to plant menthol.
Ostéocalm® gel provides a sensation of relief and comfort thanks to its cooling effect:
- Rapid endothermic evaporation.
- Prolonged by stimulating cold sensitivity with menthol.
Health benefits :
The properties of menthol
Menthol's cooling effect provides comfort according to the principle of cryotherapy.
Menthol drains, refreshes and decongests. It is therefore used in many treatments for heavy, swollen legs for immediate comfort. It is also a "cold effect" painkiller, acting on muscle and joint pain.
This active ingredient is used in particular by athletes, during the recovery phase, to relieve muscular tension.
Soothes & Refreshes
The gel is a complementary solution to the tablets Ostéocalm® tablets tablets to locally soothe sensations of overheating.
Directions for use
For whom, for what?
- Seniors, active and sporty
- Soothe and cool hot spots
- Provide a feeling of relief and comfort
How do I use it?
Apply the gel to the heated area, massaging gently.
Wash hands thoroughly after use. Close tube after use.
How many times a day?
1 to 3 times a day on heated areas.
Precautions for use
- Keep out of reach of children.
- For children over 7, application should be under adult supervision.
- Do not apply to damaged or irritated skin.
- Not for use by pregnant or breast-feeding women.
- Avoid contact with eyes and/or mucous membranes.
- In case of accidental eye contact, rinse eyes thoroughly with water or saline solution.
- Do not use if allergic to fish, menthol or alcohol.
- If irritation occurs, discontinue use immediately.
- Do not cover with a bandage.
- Do not apply with external heat, such as an electric heating pad, as this may cause excessive irritation or skin burns.
- Gel for external use.
Composition
- Promerim® hydrolyzed marine collagen
- Water
- Denatured alcohol
- Menthol
- Polyglyceryl-4 caprate
- Carbomer
- Potassium hydroxide
- Lemon eucalyptus essential oil
- Sodium stearoyl glutamate
- Gaultheria procubens leaf oil
- Citronellol
- Limonene

The science behind it: Osteocalm® Gel - The scientific evidence of Laboratoire Dielen
The clinical study presented below compares the cold effect of menthol with that of ice. It demonstrates the benefits of menthol in reducing the intensity of muscle contracture pain (VAS test).
Reference Hunter AM, Grigson C, Wade A. INFLUENCE OF TOPICALLY APPLIED MENTHOL COOLING GEL ON SOFT TISSUE THERMODYNAMICS AND ARTERIAL AND CUTANEOUS BLOOD FLOW AT REST. Int J Sports Phys Ther. 2018 Jun;13(3):483-492.
Frequently asked questions
Menthol and essential oils are not recommended during pregnancy or while breast-feeding.
There is a risk of passage through the placenta, which is dangerous for the baby.
The same applies to breast-feeding, as essential oils can pass into breast milk.
The absorption of peptides depends on their structure, and particularly on their molecular weight.
Absorption can take place by internalization if molecular weights are below 1500 daltons, or by passive diffusion when they do not exceed 500 daltons.
80% of the peptides present in Ostéocalm® Gel are less than 1500 daltons and 30% less than 300 daltons. So, in theory, Promerim® low-molecular-weight collagen peptides pass well through the skin.
The local cooling effect is almost immediate. For a more intense cooling effect, Ostéocalm® Gel can be stored in the refrigerator.
The cooling effect of menthol is felt after a few minutes. This effect is prolonged. It lasts over time.












